STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NMUNeuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. (170 aa)    
Predicted Functional Partners:
NMUR2
Neuromedin U receptor 2; Belongs to the G-protein coupled receptor 1 family.
    
 0.998
NMUR1
Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family.
    
 0.996
RASGEF1A
RasGEF domain family member 1A.
      
 0.679
HCRT
Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
      
 0.614
NTS
Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
   
  
 0.612
NMS
Neuromedin S.
      
0.601
IAPP
Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family.
      
 0.580
GHSR
Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.559
NTSR1
Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.523
NPS
Neuropeptide S.
      
 0.515
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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