STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLK11Kallikrein related peptidase 11; Belongs to the peptidase S1 family. (344 aa)    
Predicted Functional Partners:
SYT3
Synaptotagmin 3.
   
  
 0.598
EMC10
ER membrane protein complex subunit 10.
      
 0.598
APP
Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
    
 
 0.580
SPINK5
Serine peptidase inhibitor, Kazal type 5.
   
 
 0.562
TFPI
Tissue factor pathway inhibitor.
    
 
 0.530
CAPN7
Calpain 7; Belongs to the peptidase C2 family.
    
 
 0.491
ITPRID1
ITPR interacting domain containing 1.
      
 0.487
PRLHR
Prolactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.487
AMBP
Alpha-1-microglobulin/bikunin precursor.
   
 
 0.484
SPINK1
Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity).
   
 
 0.464
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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