RFX3 protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

RFX3

Regulatory factor X3. (854 aa)

Predicted Functional Partners:

FOXJ1

0.771

ATR

0.737

RFXAP

0.652

TMEM117

0.616

BCO2

0.615

NAALADL2

0.582

KBTBD12

0.569

TMEM161B

0.568

RFXANK

0.563

SLC2A13

0.562

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATR	RFX3	ENSCAFP00000011639	ENSCAFP00000060043	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Regulatory factor X3.	0.737
BCO2	KBTBD12	ENSCAFP00000020579	ENSCAFP00000006077	Beta-carotene oxygenase 2.	Kelch repeat and BTB domain containing 12.	0.802
BCO2	NAALADL2	ENSCAFP00000020579	ENSCAFP00000058020	Beta-carotene oxygenase 2.	N-acetylated alpha-linked acidic dipeptidase like 2.	0.631
BCO2	RFX3	ENSCAFP00000020579	ENSCAFP00000060043	Beta-carotene oxygenase 2.	Regulatory factor X3.	0.615
BCO2	SLC2A13	ENSCAFP00000020579	ENSCAFP00000062967	Beta-carotene oxygenase 2.	Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.638
BCO2	TMEM117	ENSCAFP00000020579	ENSCAFP00000039781	Beta-carotene oxygenase 2.	Transmembrane protein 117.	0.649
BCO2	TMEM161B	ENSCAFP00000020579	ENSCAFP00000064891	Beta-carotene oxygenase 2.	Transmembrane protein 161B.	0.620
FOXJ1	RFX3	ENSCAFP00000007529	ENSCAFP00000060043	Forkhead box J1.	Regulatory factor X3.	0.771
KBTBD12	BCO2	ENSCAFP00000006077	ENSCAFP00000020579	Kelch repeat and BTB domain containing 12.	Beta-carotene oxygenase 2.	0.802
KBTBD12	NAALADL2	ENSCAFP00000006077	ENSCAFP00000058020	Kelch repeat and BTB domain containing 12.	N-acetylated alpha-linked acidic dipeptidase like 2.	0.760
KBTBD12	RFX3	ENSCAFP00000006077	ENSCAFP00000060043	Kelch repeat and BTB domain containing 12.	Regulatory factor X3.	0.569
KBTBD12	SLC2A13	ENSCAFP00000006077	ENSCAFP00000062967	Kelch repeat and BTB domain containing 12.	Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.790
KBTBD12	TMEM117	ENSCAFP00000006077	ENSCAFP00000039781	Kelch repeat and BTB domain containing 12.	Transmembrane protein 117.	0.792
KBTBD12	TMEM161B	ENSCAFP00000006077	ENSCAFP00000064891	Kelch repeat and BTB domain containing 12.	Transmembrane protein 161B.	0.902
NAALADL2	BCO2	ENSCAFP00000058020	ENSCAFP00000020579	N-acetylated alpha-linked acidic dipeptidase like 2.	Beta-carotene oxygenase 2.	0.631
NAALADL2	KBTBD12	ENSCAFP00000058020	ENSCAFP00000006077	N-acetylated alpha-linked acidic dipeptidase like 2.	Kelch repeat and BTB domain containing 12.	0.760
NAALADL2	RFX3	ENSCAFP00000058020	ENSCAFP00000060043	N-acetylated alpha-linked acidic dipeptidase like 2.	Regulatory factor X3.	0.582
NAALADL2	SLC2A13	ENSCAFP00000058020	ENSCAFP00000062967	N-acetylated alpha-linked acidic dipeptidase like 2.	Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.751
NAALADL2	TMEM117	ENSCAFP00000058020	ENSCAFP00000039781	N-acetylated alpha-linked acidic dipeptidase like 2.	Transmembrane protein 117.	0.858
NAALADL2	TMEM161B	ENSCAFP00000058020	ENSCAFP00000064891	N-acetylated alpha-linked acidic dipeptidase like 2.	Transmembrane protein 161B.	0.764

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.805

expected number of edges:

11

PPI enrichment p-value:

0.00059

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008299

Isoprenoid biosynthetic process

8 of 15

2.15

5.32

6.34e-13

GO:0046165

Alcohol biosynthetic process

3 of 11

1.86

1.34

0.0020

GO:0016094

Polyprenol biosynthetic process

2 of 2

2.43

1.15

0.0077

GO:0009240

Isopentenyl diphosphate biosynthetic process

2 of 6

1.95

0.82

0.0279

GO:0016114

Terpenoid biosynthetic process

2 of 7

1.88

0.79

0.0313

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35336129

(2022) Production of Vitamin K by Wild-Type and Engineered Microorganisms.

2 of 7

1.88

0.98

0.0126

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:697

Isoprenoid biosynthetic process, and CTP metabolic process

8 of 17

2.1

5.13

7.93e-13

CL:717

Terpenoid backbone biosynthesis

5 of 7

2.28

3.66

4.13e-08

CL:698

Isoprene biosynthesis, and CTP metabolic process

3 of 10

1.9

1.39

0.0017

CL:699

Isoprene biosynthesis

2 of 5

2.03

0.79

0.0334

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ppc00900

Terpenoid backbone biosynthesis

7 of 13

2.16

4.98

6.33e-12

ppc01110

Biosynthesis of secondary metabolites

7 of 242

0.89

0.78

0.00033

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0414

Isoprene biosynthesis

3 of 7

2.06

1.57

0.00086

KW-0460

Magnesium

4 of 91

1.07

0.61

0.0265

KW-0479

Metal-binding

5 of 188

0.85

0.51

0.0265

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01255

Putative undecaprenyl diphosphate synthase

2 of 2

2.43

0.82

0.0316

PF00348

Polyprenyl synthetase

2 of 2

2.43

0.82

0.0316

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