node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC42-2 | IQGAP1 | ENSCAFP00000060180 | ENSCAFP00000018867 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | IQ motif containing GTPase activating protein 1. | 0.981 |
CDC42-2 | PAK1 | ENSCAFP00000060180 | ENSCAFP00000044903 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Non-specific serine/threonine protein kinase. | 0.989 |
CDC42-2 | PAK3 | ENSCAFP00000060180 | ENSCAFP00000007390 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | P21 (RAC1) activated kinase 3. | 0.972 |
CDC42-2 | PAK4 | ENSCAFP00000060180 | ENSCAFP00000059698 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Non-specific serine/threonine protein kinase. | 0.977 |
CDC42-2 | PAK6 | ENSCAFP00000060180 | ENSCAFP00000013235 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Non-specific serine/threonine protein kinase. | 0.970 |
CDC42-2 | PARD6A | ENSCAFP00000060180 | ENSCAFP00000040187 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Par-6 family cell polarity regulator alpha. | 0.973 |
CDC42-2 | PARD6G | ENSCAFP00000060180 | ENSCAFP00000000006 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Par-6 family cell polarity regulator gamma. | 0.973 |
CDC42-2 | PIK3CB | ENSCAFP00000060180 | ENSCAFP00000011245 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.972 |
CDC42-2 | SRC | ENSCAFP00000060180 | ENSCAFP00000044994 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Tyrosine-protein kinase. | 0.974 |
CDC42-2 | WASL | ENSCAFP00000060180 | ENSCAFP00000066640 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | WASP like actin nucleation promoting factor. | 0.974 |
IQGAP1 | CDC42-2 | ENSCAFP00000018867 | ENSCAFP00000060180 | IQ motif containing GTPase activating protein 1. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.981 |
IQGAP1 | PAK1 | ENSCAFP00000018867 | ENSCAFP00000044903 | IQ motif containing GTPase activating protein 1. | Non-specific serine/threonine protein kinase. | 0.511 |
IQGAP1 | PAK3 | ENSCAFP00000018867 | ENSCAFP00000007390 | IQ motif containing GTPase activating protein 1. | P21 (RAC1) activated kinase 3. | 0.471 |
IQGAP1 | PAK4 | ENSCAFP00000018867 | ENSCAFP00000059698 | IQ motif containing GTPase activating protein 1. | Non-specific serine/threonine protein kinase. | 0.498 |
IQGAP1 | PAK6 | ENSCAFP00000018867 | ENSCAFP00000013235 | IQ motif containing GTPase activating protein 1. | Non-specific serine/threonine protein kinase. | 0.749 |
IQGAP1 | PARD6A | ENSCAFP00000018867 | ENSCAFP00000040187 | IQ motif containing GTPase activating protein 1. | Par-6 family cell polarity regulator alpha. | 0.489 |
IQGAP1 | SRC | ENSCAFP00000018867 | ENSCAFP00000044994 | IQ motif containing GTPase activating protein 1. | Tyrosine-protein kinase. | 0.582 |
IQGAP1 | WASL | ENSCAFP00000018867 | ENSCAFP00000066640 | IQ motif containing GTPase activating protein 1. | WASP like actin nucleation promoting factor. | 0.715 |
PAK1 | CDC42-2 | ENSCAFP00000044903 | ENSCAFP00000060180 | Non-specific serine/threonine protein kinase. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.989 |
PAK1 | IQGAP1 | ENSCAFP00000044903 | ENSCAFP00000018867 | Non-specific serine/threonine protein kinase. | IQ motif containing GTPase activating protein 1. | 0.511 |