STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KDM2BLysine demethylase 2B. (1397 aa)    
Predicted Functional Partners:
PCGF1
Polycomb group ring finger 1.
   
 
 0.976
SKP1
S-phase kinase associated protein 1; Belongs to the SKP1 family.
   
 
 0.922
ENSCAFP00000049197
Uncharacterized protein; Belongs to the SKP1 family.
   
 
 0.922
ENSCAFP00000051783
Uncharacterized protein; Belongs to the SKP1 family.
   
 
 0.922
ENSCAFP00000063226
Uncharacterized protein; Belongs to the SKP1 family.
   
 
 0.922
RYBP
RING1 and YY1 binding protein.
    
 
 0.918
BCORL1
BCL6 corepressor like 1.
   
 
 0.916
RING1
E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...]
   
 
 0.894
YAF2
YY1 associated factor 2.
    
 
 0.879
RNF2
Ring finger protein 2.
   
 
 0.878
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.