node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT3 | ATF2 | ENSCAFP00000023241 | ENSCAFP00000019690 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | 0.912 |
AKT3 | CREB1 | ENSCAFP00000023241 | ENSCAFP00000019912 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | cAMP responsive element binding protein 1. | 0.943 |
AKT3 | CREB5 | ENSCAFP00000023241 | ENSCAFP00000060664 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | cAMP responsive element binding protein 5. | 0.938 |
AKT3 | EP300 | ENSCAFP00000023241 | ENSCAFP00000001585 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | E1A binding protein p300. | 0.413 |
AKT3 | MAPK1 | ENSCAFP00000023241 | ENSCAFP00000030998 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.924 |
ATF2 | AKT3 | ENSCAFP00000019690 | ENSCAFP00000023241 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.912 |
ATF2 | CREB1 | ENSCAFP00000019690 | ENSCAFP00000019912 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | cAMP responsive element binding protein 1. | 0.956 |
ATF2 | CREB5 | ENSCAFP00000019690 | ENSCAFP00000060664 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | cAMP responsive element binding protein 5. | 0.960 |
ATF2 | CREBBP | ENSCAFP00000019690 | ENSCAFP00000036447 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | CREB binding protein. | 0.950 |
ATF2 | EP300 | ENSCAFP00000019690 | ENSCAFP00000001585 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | E1A binding protein p300. | 0.905 |
ATF2 | MAPK1 | ENSCAFP00000019690 | ENSCAFP00000030998 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.953 |
ATF2 | PPP1CA | ENSCAFP00000019690 | ENSCAFP00000017060 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.914 |
ATF2 | PRKACA | ENSCAFP00000019690 | ENSCAFP00000053880 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.916 |
ATF2 | PRKACB | ENSCAFP00000019690 | ENSCAFP00000030135 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.915 |
ATF2 | PRKCB | ENSCAFP00000019690 | ENSCAFP00000025992 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.902 |
CREB1 | AKT3 | ENSCAFP00000019912 | ENSCAFP00000023241 | cAMP responsive element binding protein 1. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.943 |
CREB1 | ATF2 | ENSCAFP00000019912 | ENSCAFP00000019690 | cAMP responsive element binding protein 1. | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | 0.956 |
CREB1 | CREB5 | ENSCAFP00000019912 | ENSCAFP00000060664 | cAMP responsive element binding protein 1. | cAMP responsive element binding protein 5. | 0.934 |
CREB1 | CREBBP | ENSCAFP00000019912 | ENSCAFP00000036447 | cAMP responsive element binding protein 1. | CREB binding protein. | 0.999 |
CREB1 | EP300 | ENSCAFP00000019912 | ENSCAFP00000001585 | cAMP responsive element binding protein 1. | E1A binding protein p300. | 0.985 |