STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CA4Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (322 aa)    
Predicted Functional Partners:
CA12
Carbonic anhydrase 12; Belongs to the alpha-carbonic anhydrase family.
  
 
0.626
CA9
Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family.
  
  
0.620
CA14
Carbonic anhydrase 14; Belongs to the alpha-carbonic anhydrase family.
  
 
0.611
RPF2
Ribosome production factor 2 homolog.
   
 
 0.604
RP9
RP9 pre-mRNA splicing factor.
      
 0.578
PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
      
 0.570
SEMA4A
Semaphorin 4A; Belongs to the semaphorin family.
   
  
 0.565
PRPF31
Nop domain-containing protein.
   
  
 0.541
IMPDH1
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
   
  
 0.523
CRISP1
SCP domain-containing protein; Belongs to the CRISP family.
   
  
 0.521
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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