SH3BP1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SH3BP1

SH3 domain binding protein 1. (808 aa)

Predicted Functional Partners:

PDXP

0.753

ARHGAP17

0.580

SH3KBP1

0.546

ARHGAP44

0.527

RAC1

0.518

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP17	ARHGAP44	ENSCAFP00000025772	ENSCAFP00000026386	Rho GTPase activating protein 17.	Rho GTPase activating protein 44.	0.529
ARHGAP17	RAC1	ENSCAFP00000025772	ENSCAFP00000032062	Rho GTPase activating protein 17.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.499
ARHGAP17	SH3BP1	ENSCAFP00000025772	ENSCAFP00000060881	Rho GTPase activating protein 17.	SH3 domain binding protein 1.	0.580
ARHGAP17	SH3KBP1	ENSCAFP00000025772	ENSCAFP00000058783	Rho GTPase activating protein 17.	SH3 domain containing kinase binding protein 1.	0.546
ARHGAP44	ARHGAP17	ENSCAFP00000026386	ENSCAFP00000025772	Rho GTPase activating protein 44.	Rho GTPase activating protein 17.	0.529
ARHGAP44	RAC1	ENSCAFP00000026386	ENSCAFP00000032062	Rho GTPase activating protein 44.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.511
ARHGAP44	SH3BP1	ENSCAFP00000026386	ENSCAFP00000060881	Rho GTPase activating protein 44.	SH3 domain binding protein 1.	0.527
PDXP	SH3BP1	ENSCAFP00000036903	ENSCAFP00000060881	Pyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily.	SH3 domain binding protein 1.	0.753
RAC1	ARHGAP17	ENSCAFP00000032062	ENSCAFP00000025772	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	Rho GTPase activating protein 17.	0.499
RAC1	ARHGAP44	ENSCAFP00000032062	ENSCAFP00000026386	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	Rho GTPase activating protein 44.	0.511
RAC1	SH3BP1	ENSCAFP00000032062	ENSCAFP00000060881	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	SH3 domain binding protein 1.	0.518
SH3BP1	ARHGAP17	ENSCAFP00000060881	ENSCAFP00000025772	SH3 domain binding protein 1.	Rho GTPase activating protein 17.	0.580
SH3BP1	ARHGAP44	ENSCAFP00000060881	ENSCAFP00000026386	SH3 domain binding protein 1.	Rho GTPase activating protein 44.	0.527
SH3BP1	PDXP	ENSCAFP00000060881	ENSCAFP00000036903	SH3 domain binding protein 1.	Pyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily.	0.753
SH3BP1	RAC1	ENSCAFP00000060881	ENSCAFP00000032062	SH3 domain binding protein 1.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.518
SH3BP1	SH3KBP1	ENSCAFP00000060881	ENSCAFP00000058783	SH3 domain binding protein 1.	SH3 domain containing kinase binding protein 1.	0.546
SH3KBP1	ARHGAP17	ENSCAFP00000058783	ENSCAFP00000025772	SH3 domain containing kinase binding protein 1.	Rho GTPase activating protein 17.	0.546
SH3KBP1	SH3BP1	ENSCAFP00000058783	ENSCAFP00000060881	SH3 domain containing kinase binding protein 1.	SH3 domain binding protein 1.	0.546