STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SP110SP110 nuclear body protein. (762 aa)    
Predicted Functional Partners:
OSBPL9
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.775
STXBP5
Syntaxin binding protein 5.
      
 0.711
KBTBD3
Kelch repeat and BTB domain containing 3.
    
 
 0.680
ABHD1
Abhydrolase domain containing 1.
      
 0.572
STXBP5L
Syntaxin binding protein 5 like.
      
 0.568
CSNK2A1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 
 0.550
PARP9
Poly(ADP-ribose) polymerase family member 9.
   
 
 0.549
DDX58
DExD/H-box helicase 58.
   
 
 0.548
TCIRG1
V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
      
 0.522
SLC11A1
Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...]
   
  
 0.522
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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