SPARC protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SPARC

Secreted protein acidic and cysteine rich. (361 aa)

Predicted Functional Partners:

LUM

0.987

COL1A2

0.947

COL1A1

0.925

DCN

0.897

SPP1

0.861

STAB1

0.823

APOB

0.805

COL3A1

0.769

FSTL1

0.710

BGN

0.699

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOB	SPARC	ENSCAFP00000005806	ENSCAFP00000060949	Apolipoprotein B.	Secreted protein acidic and cysteine rich.	0.805
APOB	STAB1	ENSCAFP00000005806	ENSCAFP00000013716	Apolipoprotein B.	Stabilin 1.	0.848
BGN	COL1A1	ENSCAFP00000028297	ENSCAFP00000025056	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	0.874
BGN	COL1A2	ENSCAFP00000028297	ENSCAFP00000029400	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family.	0.823
BGN	COL3A1	ENSCAFP00000028297	ENSCAFP00000021825	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen type III alpha 1 chain.	0.726
BGN	DCN	ENSCAFP00000028297	ENSCAFP00000009230	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.891
BGN	LUM	ENSCAFP00000028297	ENSCAFP00000009219	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Lumican.	0.696
BGN	SPARC	ENSCAFP00000028297	ENSCAFP00000060949	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Secreted protein acidic and cysteine rich.	0.699
BGN	SPP1	ENSCAFP00000028297	ENSCAFP00000035550	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Secreted phosphoprotein 1.	0.513
COL1A1	BGN	ENSCAFP00000025056	ENSCAFP00000028297	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.874
COL1A1	COL1A2	ENSCAFP00000025056	ENSCAFP00000029400	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family.	0.999
COL1A1	COL3A1	ENSCAFP00000025056	ENSCAFP00000021825	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	Collagen type III alpha 1 chain.	0.996
COL1A1	DCN	ENSCAFP00000025056	ENSCAFP00000009230	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.829
COL1A1	FSTL1	ENSCAFP00000025056	ENSCAFP00000036298	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	Follistatin like 1.	0.541
COL1A1	LUM	ENSCAFP00000025056	ENSCAFP00000009219	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	Lumican.	0.855
COL1A1	SPARC	ENSCAFP00000025056	ENSCAFP00000060949	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	Secreted protein acidic and cysteine rich.	0.925
COL1A1	SPP1	ENSCAFP00000025056	ENSCAFP00000035550	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	Secreted phosphoprotein 1.	0.703
COL1A2	BGN	ENSCAFP00000029400	ENSCAFP00000028297	Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family.	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.823
COL1A2	COL1A1	ENSCAFP00000029400	ENSCAFP00000025056	Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family.	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	0.999
COL1A2	COL3A1	ENSCAFP00000029400	ENSCAFP00000021825	Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family.	Collagen type III alpha 1 chain.	0.995

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.887

expected number of edges:

10

PPI enrichment p-value:

4.36e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070897

Transcription preinitiation complex assembly

6 of 21

2.77

6.0

3.71e-12

GO:0006352

DNA-templated transcription, initiation

7 of 73

2.3

5.37

3.71e-12

GO:0006351

Transcription, DNA-templated

9 of 285

1.82

4.06

3.71e-12

GO:0051123

RNA polymerase II preinitiation complex assembly

4 of 12

2.84

4.02

3.56e-08

GO:0006366

Transcription by RNA polymerase II

5 of 169

1.79

2.32

4.58e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140296

General transcription initiation factor binding

4 of 34

2.39

2.74

5.68e-06

GO:0017025

TBP-class protein binding

3 of 16

2.59

2.24

7.14e-05

GO:0016251

RNA polymerase II general transcription initiation factor activity

3 of 22

2.45

2.08

0.00013

GO:0008134

Transcription factor binding

6 of 358

1.54

1.91

9.04e-06

GO:0061629

RNA polymerase II-specific DNA-binding transcription factor binding

4 of 188

1.65

1.43

0.00068

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055029

Nuclear DNA-directed RNA polymerase complex

7 of 97

2.18

4.9

1.34e-11

GO:0005669

Transcription factor TFIID complex

5 of 27

2.59

4.83

4.47e-10

GO:0005667

Transcription regulator complex

8 of 371

1.65

3.14

2.63e-10

GO:0000126

Transcription factor TFIIIB complex

2 of 4

3.02

1.98

0.00026

GO:0097550

Transcription preinitiation complex

2 of 9

2.66

1.66

0.00091

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10520

RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription Initiation

9 of 159

2.07

5.58

1.36e-14

CL:10650

Basal transcription factors, and Transcription factor TFIID complex

5 of 37

2.45

4.1

9.35e-09

CL:10753

RNA polymerase III complex, and RNA polymerase I complex

4 of 29

2.46

3.2

7.35e-07

CL:10657

RNA polymerase II preinitiation complex assembly, and CENP-S protein

3 of 12

2.72

2.6

1.56e-05

CL:10755

RNA polymerase III complex

3 of 21

2.47

2.25

5.95e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03022

Basal transcription factors

3 of 29

2.33

2.19

6.77e-05

pret03020

RNA polymerase

2 of 25

2.22

1.18

0.0061

pret04623

Cytosolic DNA-sensing pathway

2 of 34

2.09

1.13

0.0073

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6807505

RNA polymerase II transcribes snRNA genes

7 of 104

2.15

4.72

2.83e-11

MAP-76071

RNA Polymerase III Transcription Initiation From Type 3 Promoter

5 of 29

2.55

4.58

1.36e-09

MAP-76046

RNA Polymerase III Transcription Initiation

5 of 42

2.39

4.15

5.61e-09

MAP-74158

RNA Polymerase III Transcription

5 of 48

2.34

4.02

8.38e-09

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

5 of 53

2.29

3.92

1.11e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 95

1.94

1.85

0.00016

GOCC:0097550

Transcription preinitiation complex

2 of 6

2.84

1.51

0.0018

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

3 of 85

1.87

1.35

0.0019

GOCC:1990234

Transferase complex

6 of 794

1.2

1.12

0.00037

GOCC:0005654

Nucleoplasm

4 of 572

1.16

0.69

0.0194

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

2 of 13

2.5

1.16

0.0074

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013150

Transcription factor TFIIB, cyclin-like domain

2 of 4

3.02

0.92

0.0224

IPR013137

Zinc finger, TFIIB-type

2 of 4

3.02

0.92

0.0224

IPR000812

Transcription factor TFIIB

2 of 4

3.02

0.92

0.0224

IPR009072

Histone-fold

3 of 70

1.95

0.87

0.0224

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About