HMGCR protein (Canis lupus familiaris) - STRING interaction network

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Score

HMGCR

3-hydroxy-3-methylglutaryl coenzyme A reductase. (935 aa)

Predicted Functional Partners:

HMGCS1

0.999

HMGCS2

0.998

SQLE

0.967

MVK

0.947

PRKAG2

0.927

CYP51A1

0.922

PRKAG3

0.916

PRKAG1

0.916

PRKAA1

0.914

PRKAA2

0.913

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP51A1	HMGCR	ENSCAFP00000002855	ENSCAFP00000061137	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.922
CYP51A1	HMGCS1	ENSCAFP00000002855	ENSCAFP00000027406	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.942
CYP51A1	HMGCS2	ENSCAFP00000002855	ENSCAFP00000014843	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.868
CYP51A1	MVK	ENSCAFP00000002855	ENSCAFP00000039573	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.595
CYP51A1	SQLE	ENSCAFP00000002855	ENSCAFP00000034027	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Squalene epoxidase.	0.967
HMGCR	CYP51A1	ENSCAFP00000061137	ENSCAFP00000002855	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	0.922
HMGCR	HMGCS1	ENSCAFP00000061137	ENSCAFP00000027406	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
HMGCR	HMGCS2	ENSCAFP00000061137	ENSCAFP00000014843	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.998
HMGCR	MVK	ENSCAFP00000061137	ENSCAFP00000039573	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.947
HMGCR	PRKAA1	ENSCAFP00000061137	ENSCAFP00000050809	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Non-specific serine/threonine protein kinase.	0.914
HMGCR	PRKAA2	ENSCAFP00000061137	ENSCAFP00000027993	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Non-specific serine/threonine protein kinase.	0.913
HMGCR	PRKAG1	ENSCAFP00000061137	ENSCAFP00000012869	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.916
HMGCR	PRKAG2	ENSCAFP00000061137	ENSCAFP00000007340	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.927
HMGCR	PRKAG3	ENSCAFP00000061137	ENSCAFP00000007343	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.916
HMGCR	SQLE	ENSCAFP00000061137	ENSCAFP00000034027	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Squalene epoxidase.	0.967
HMGCS1	CYP51A1	ENSCAFP00000027406	ENSCAFP00000002855	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	0.942
HMGCS1	HMGCR	ENSCAFP00000027406	ENSCAFP00000061137	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999
HMGCS1	HMGCS2	ENSCAFP00000027406	ENSCAFP00000014843	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.916
HMGCS1	MVK	ENSCAFP00000027406	ENSCAFP00000039573	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.798
HMGCS1	SQLE	ENSCAFP00000027406	ENSCAFP00000034027	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Squalene epoxidase.	0.966