STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PNKPPolynucleotide kinase 3'-phosphatase. (589 aa)    
Predicted Functional Partners:
XRCC1
Uncharacterized protein.
   
 0.971
POLB
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
    
 0.938
TTF2
Transcription termination factor 2.
  
 
 0.927
LIG3
DNA ligase.
   
 0.851
NEIL1
Nei like DNA glycosylase 1.
     
 0.762
NEIL2
Nei like DNA glycosylase 2.
     
 0.748
HTT
Huntingtin.
   
 
 0.724
FCSK
Fucose kinase.
  
  
 0.720
TDP1
Tyrosyl-DNA phosphodiesterase 1.
    
 
 0.716
PARP2
Poly [ADP-ribose] polymerase.
   
 
 0.710
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.