STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (744 aa)    
Predicted Functional Partners:
GRIN2B
Glutamate receptor ionotropic, NMDA 2B; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator fo [...]
   
 0.991
GRIN2A
Glutamate ionotropic receptor NMDA type subunit 2A.
   
 0.990
GRIN1
Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
   
 0.989
DLGAP1
DLG associated protein 1.
   
 0.977
GRIN3A
Glutamate ionotropic receptor NMDA type subunit 3A.
   
 0.953
GRIN2C
Glutamate ionotropic receptor NMDA type subunit 2C.
    
 0.951
DLG3
Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.
  
 
0.950
LLGL2
LLGL scribble cell polarity complex component 2.
   
 0.949
LLGL1
LLGL scribble cell polarity complex component 1.
   
 0.949
GRIN2D
Glutamate ionotropic receptor NMDA type subunit 2D; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
    
 0.939
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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