node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTNNB1 | ENSCAFP00000058542 | ENSCAFP00000007783 | ENSCAFP00000058542 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Uncharacterized protein. | 0.435 |
CTNNB1 | ENSCAFP00000061379 | ENSCAFP00000007783 | ENSCAFP00000061379 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | POU-specific domain-containing protein. | 0.589 |
CTNNB1 | NANOG | ENSCAFP00000007783 | ENSCAFP00000020496 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Homeobox domain-containing protein. | 0.665 |
CTNNB1 | SALL4 | ENSCAFP00000007783 | ENSCAFP00000017287 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Spalt like transcription factor 4. | 0.487 |
CTNNB1 | SOX17 | ENSCAFP00000007783 | ENSCAFP00000037797 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | SRY-box 17. | 0.625 |
CTNNB1 | SOX3 | ENSCAFP00000007783 | ENSCAFP00000028081 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | SRY-box 3. | 0.651 |
CTNNB1 | SOX4 | ENSCAFP00000007783 | ENSCAFP00000034212 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Transcription factor SOX. | 0.494 |
ENSCAFP00000058542 | CTNNB1 | ENSCAFP00000058542 | ENSCAFP00000007783 | Uncharacterized protein. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.435 |
ENSCAFP00000058542 | ENSCAFP00000061379 | ENSCAFP00000058542 | ENSCAFP00000061379 | Uncharacterized protein. | POU-specific domain-containing protein. | 0.680 |
ENSCAFP00000058542 | ESRRB | ENSCAFP00000058542 | ENSCAFP00000050405 | Uncharacterized protein. | Estrogen related receptor beta. | 0.531 |
ENSCAFP00000058542 | SALL4 | ENSCAFP00000058542 | ENSCAFP00000017287 | Uncharacterized protein. | Spalt like transcription factor 4. | 0.786 |
ENSCAFP00000058542 | SOX17 | ENSCAFP00000058542 | ENSCAFP00000037797 | Uncharacterized protein. | SRY-box 17. | 0.709 |
ENSCAFP00000058542 | SOX3 | ENSCAFP00000058542 | ENSCAFP00000028081 | Uncharacterized protein. | SRY-box 3. | 0.657 |
ENSCAFP00000058542 | SOX7 | ENSCAFP00000058542 | ENSCAFP00000032692 | Uncharacterized protein. | Uncharacterized protein. | 0.451 |
ENSCAFP00000061379 | CTNNB1 | ENSCAFP00000061379 | ENSCAFP00000007783 | POU-specific domain-containing protein. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.589 |
ENSCAFP00000061379 | ENSCAFP00000058542 | ENSCAFP00000061379 | ENSCAFP00000058542 | POU-specific domain-containing protein. | Uncharacterized protein. | 0.680 |
ENSCAFP00000061379 | ESRRB | ENSCAFP00000061379 | ENSCAFP00000050405 | POU-specific domain-containing protein. | Estrogen related receptor beta. | 0.548 |
ENSCAFP00000061379 | NANOG | ENSCAFP00000061379 | ENSCAFP00000020496 | POU-specific domain-containing protein. | Homeobox domain-containing protein. | 0.680 |
ENSCAFP00000061379 | SALL4 | ENSCAFP00000061379 | ENSCAFP00000017287 | POU-specific domain-containing protein. | Spalt like transcription factor 4. | 0.677 |
ENSCAFP00000061379 | SOX15 | ENSCAFP00000061379 | ENSCAFP00000024504 | POU-specific domain-containing protein. | SRY-box 15. | 0.565 |