ARHGEF7 protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

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[Homology]

Score

ARHGEF7

Rho guanine nucleotide exchange factor 7. (807 aa)

Predicted Functional Partners:

GIT1

0.984

PAK2

0.970

PAK3

0.960

PAK1

0.959

PAK6

0.949

CDC42-2

0.945

PAK5

0.939

RAC2

0.937

RAC3

0.936

ARHGEF12

0.936

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF12	ARHGEF7	ENSCAFP00000017590	ENSCAFP00000061674	Rho guanine nucleotide exchange factor 12.	Rho guanine nucleotide exchange factor 7.	0.936
ARHGEF12	PAK6	ENSCAFP00000017590	ENSCAFP00000013235	Rho guanine nucleotide exchange factor 12.	Non-specific serine/threonine protein kinase.	0.571
ARHGEF7	ARHGEF12	ENSCAFP00000061674	ENSCAFP00000017590	Rho guanine nucleotide exchange factor 7.	Rho guanine nucleotide exchange factor 12.	0.936
ARHGEF7	CDC42-2	ENSCAFP00000061674	ENSCAFP00000060180	Rho guanine nucleotide exchange factor 7.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.945
ARHGEF7	GIT1	ENSCAFP00000061674	ENSCAFP00000027951	Rho guanine nucleotide exchange factor 7.	GIT ArfGAP 1.	0.984
ARHGEF7	PAK1	ENSCAFP00000061674	ENSCAFP00000044903	Rho guanine nucleotide exchange factor 7.	Non-specific serine/threonine protein kinase.	0.959
ARHGEF7	PAK2	ENSCAFP00000061674	ENSCAFP00000064510	Rho guanine nucleotide exchange factor 7.	Non-specific serine/threonine protein kinase.	0.970
ARHGEF7	PAK3	ENSCAFP00000061674	ENSCAFP00000007390	Rho guanine nucleotide exchange factor 7.	P21 (RAC1) activated kinase 3.	0.960
ARHGEF7	PAK5	ENSCAFP00000061674	ENSCAFP00000008503	Rho guanine nucleotide exchange factor 7.	Non-specific serine/threonine protein kinase.	0.939
ARHGEF7	PAK6	ENSCAFP00000061674	ENSCAFP00000013235	Rho guanine nucleotide exchange factor 7.	Non-specific serine/threonine protein kinase.	0.949
ARHGEF7	RAC2	ENSCAFP00000061674	ENSCAFP00000002174	Rho guanine nucleotide exchange factor 7.	Rac family small GTPase 2.	0.937
ARHGEF7	RAC3	ENSCAFP00000061674	ENSCAFP00000008868	Rho guanine nucleotide exchange factor 7.	Uncharacterized protein.	0.936
CDC42-2	ARHGEF7	ENSCAFP00000060180	ENSCAFP00000061674	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rho guanine nucleotide exchange factor 7.	0.945
CDC42-2	GIT1	ENSCAFP00000060180	ENSCAFP00000027951	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	GIT ArfGAP 1.	0.605
CDC42-2	PAK1	ENSCAFP00000060180	ENSCAFP00000044903	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Non-specific serine/threonine protein kinase.	0.989
CDC42-2	PAK2	ENSCAFP00000060180	ENSCAFP00000064510	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Non-specific serine/threonine protein kinase.	0.968
CDC42-2	PAK3	ENSCAFP00000060180	ENSCAFP00000007390	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	P21 (RAC1) activated kinase 3.	0.972
CDC42-2	PAK5	ENSCAFP00000060180	ENSCAFP00000008503	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Non-specific serine/threonine protein kinase.	0.969
CDC42-2	PAK6	ENSCAFP00000060180	ENSCAFP00000013235	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Non-specific serine/threonine protein kinase.	0.970
CDC42-2	RAC2	ENSCAFP00000060180	ENSCAFP00000002174	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rac family small GTPase 2.	0.919