STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRP8LDL receptor related protein 8. (1044 aa)    
Predicted Functional Partners:
RELN
Reelin.
   
 
 0.954
DAB1
DAB adaptor protein 1.
    
 
 0.787
APOB
Apolipoprotein B.
    
 0.749
LRPAP1
LDL receptor related protein associated protein 1.
    
 
 0.714
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
    
 
 0.691
AGRN
Agrin.
   
 0.670
APOE
Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]
   
 
 0.665
GPC4
Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
     
 0.588
FGR
Tyrosine-protein kinase.
   
 0.540
LDLRAP1
Low density lipoprotein receptor adaptor protein 1.
   
 
 0.533
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.