STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIPSNAP2Nipsnap homolog 2. (286 aa)    
Predicted Functional Partners:
SMIM12
Small integral membrane protein 12.
   
  
 0.663
PAAF1
Proteasomal ATPase associated factor 1.
   
  
 0.553
PSMD1
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
   
    0.545
MTHFSD
Methenyltetrahydrofolate synthetase domain containing.
   
    0.543
MTHFSD-2
Uncharacterized protein.
   
    0.543
UTP15
UTP15 small subunit processome component.
   
    0.542
WDR6
WD repeat domain 6.
   
    0.542
PAK4
Non-specific serine/threonine protein kinase.
   
 
 0.532
NOP56
NOP56 ribonucleoprotein.
   
    0.526
NPAS4
Neuronal PAS domain protein 4.
   
    0.526
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.