STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDLIM2PDZ and LIM domain 2. (687 aa)    
Predicted Functional Partners:
LIMD1
LIM domains containing 1.
   
 
 0.592
PTPN1
Tyrosine-protein phosphatase non-receptor type.
   
 
 0.569
COMMD1
COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquiti [...]
   
  
 0.567
KRT36
Keratin 36; Belongs to the intermediate filament family.
    
 
 0.523
PAMR1
Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.
      
 0.523
LIMD2
LIM domain containing 2.
   
  
 0.521
C20orf27
Chromosome 20 open reading frame 27.
   
 
 0.518
DDI1
DNA damage inducible 1 homolog 1.
      
 0.515
ACTN4
Actinin alpha 4.
   
 
 0.514
CHD1
Chromodomain helicase DNA binding protein 1.
      
 0.513
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.