STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H1-0H1 histone family member 0. (194 aa)    
Predicted Functional Partners:
KPNB1
Karyopherin subunit beta 1.
    
   0.876
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 
 0.779
DFFB
DNA fragmentation factor subunit beta.
    
 0.673
CDK3
Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.
   
 
 0.626
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 
 0.614
HMGB1
High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]
   
 0.585
HMGB2
High mobility group box 2.
   
 0.570
RBP3
Retinol binding protein 3.
      
 0.563
H1-8
H15 domain-containing protein.
    
 
 0.538
H1FOO
Uncharacterized protein.
    
 
 0.538
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.