STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1342 aa)    
Predicted Functional Partners:
RAD51B
RAD51 paralog B.
      
 0.859
ZFYVE26
Zinc finger FYVE-type containing 26.
   
  
 0.811
RRAD
GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.
   
  
 0.532
BRCA2
BRCA2 DNA repair associated.
      
 0.526
RBBP7
RB binding protein 7, chromatin remodeling factor.
   
  
 0.517
POLR3GL
DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
      
 0.499
UBR4
Ubiquitin protein ligase E3 component n-recognin 4.
      
 0.485
CLCA4
Chloride channel accessory 4.
   
  
 0.482
ESF1
ESF1 nucleolar pre-rRNA processing protein homolog.
      
 0.480
C18H7orf57
Chromosome 18 C7orf57 homolog.
      
 0.470
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.