IL6ST protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

IL6ST

Uncharacterized protein. (954 aa)

Predicted Functional Partners:

IL6

0.977

LIF

0.956

STAT3

0.951

IL6R

0.950

JAK1

0.949

LIFR

0.939

OSM

0.937

JAK3

0.918

JAK2

0.915

CTF1

0.913

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTF1	IL6	ENSCAFP00000024588	ENSCAFP00000053025	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.576
CTF1	IL6R	ENSCAFP00000024588	ENSCAFP00000025308	Uncharacterized protein.	Interleukin 6 receptor.	0.725
CTF1	IL6ST	ENSCAFP00000024588	ENSCAFP00000062759	Uncharacterized protein.	Uncharacterized protein.	0.913
CTF1	JAK1	ENSCAFP00000024588	ENSCAFP00000039978	Uncharacterized protein.	Tyrosine-protein kinase.	0.629
CTF1	JAK2	ENSCAFP00000024588	ENSCAFP00000044346	Uncharacterized protein.	Janus kinase 2.	0.644
CTF1	LIF	ENSCAFP00000024588	ENSCAFP00000036140	Uncharacterized protein.	LIF interleukin 6 family cytokine.	0.859
CTF1	LIFR	ENSCAFP00000024588	ENSCAFP00000047973	Uncharacterized protein.	Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).	0.975
CTF1	OSM	ENSCAFP00000024588	ENSCAFP00000018361	Uncharacterized protein.	Oncostatin M.	0.943
CTF1	STAT3	ENSCAFP00000024588	ENSCAFP00000050468	Uncharacterized protein.	Signal transducer and activator of transcription.	0.555
IL6	CTF1	ENSCAFP00000053025	ENSCAFP00000024588	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Uncharacterized protein.	0.576
IL6	IL6R	ENSCAFP00000053025	ENSCAFP00000025308	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Interleukin 6 receptor.	0.999
IL6	IL6ST	ENSCAFP00000053025	ENSCAFP00000062759	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Uncharacterized protein.	0.977
IL6	JAK1	ENSCAFP00000053025	ENSCAFP00000039978	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.978
IL6	JAK2	ENSCAFP00000053025	ENSCAFP00000044346	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Janus kinase 2.	0.979
IL6	JAK3	ENSCAFP00000053025	ENSCAFP00000041505	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.879
IL6	LIF	ENSCAFP00000053025	ENSCAFP00000036140	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	LIF interleukin 6 family cytokine.	0.727
IL6	LIFR	ENSCAFP00000053025	ENSCAFP00000047973	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).	0.880
IL6	OSM	ENSCAFP00000053025	ENSCAFP00000018361	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Oncostatin M.	0.764
IL6	STAT3	ENSCAFP00000053025	ENSCAFP00000050468	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Signal transducer and activator of transcription.	0.973
IL6R	CTF1	ENSCAFP00000025308	ENSCAFP00000024588	Interleukin 6 receptor.	Uncharacterized protein.	0.725