STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCAFP00000062842BHLH domain-containing protein. (70 aa)    
Predicted Functional Partners:
FBXW9
F-box and WD repeat domain containing 9.
    
 
 0.651
ARNT
Aryl hydrocarbon receptor nuclear translocator.
    
 
 0.625
ARNT2
Aryl hydrocarbon receptor nuclear translocator 2.
    
 
 0.625
VHL
Von Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity).
    
 
 0.615
NR3C2
Nuclear receptor subfamily 3 group C member 2.
   
 
 0.556
ZNF143
Zinc finger protein 143.
    
 
 0.527
EGLN1
Egl-9 family hypoxia inducible factor 1.
    
 
 0.515
EGLN3
Egl-9 family hypoxia inducible factor 3.
    
 
 0.515
EGLN2
Egl-9 family hypoxia inducible factor 2.
    
 
 0.515
NUDT2
Nudix hydrolase 2.
      
 0.485
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.