STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VPS33BVPS33B late endosome and lysosome associated; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)    
Predicted Functional Partners:
VIPAS39
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog.
   
 
 0.984
VPS11
Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.
   
 
 0.938
VPS16
Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.
   
 
 0.933
VPS39
VPS39 subunit of HOPS complex.
   
 
 0.929
VPS18
VPS18 core subunit of CORVET and HOPS complexes.
   
 
 0.920
VPS8
VPS8 subunit of CORVET complex.
    
 
 0.915
CCZ1
Uncharacterized protein.
   
 
 0.902
TGFBRAP1
Transforming growth factor beta receptor associated protein 1.
   
 
 0.886
VPS41
Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.
   
 
 0.884
VTI1A
Vesicle transport through interaction with t-SNAREs 1A.
   
 
 0.871
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.