NTRK2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NTRK2

Tyrosine-protein kinase receptor. (838 aa)

Predicted Functional Partners:

NTF4

0.994

BDNF

0.993

NTF3

0.972

PLCG1

0.957

SHC3

0.952

SHC1

0.952

PLCG2

0.938

FRS2

0.934

GRB2

0.930

SHC2

0.928

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	FRS2	ENSCAFP00000014984	ENSCAFP00000000625	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Fibroblast growth factor receptor substrate 2.	0.644
BDNF	GRB2	ENSCAFP00000014984	ENSCAFP00000049390	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Growth factor receptor bound protein 2.	0.582
BDNF	NTF3	ENSCAFP00000014984	ENSCAFP00000022527	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.842
BDNF	NTF4	ENSCAFP00000014984	ENSCAFP00000005718	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Neurotrophin 4; Belongs to the NGF-beta family.	0.944
BDNF	NTRK2	ENSCAFP00000014984	ENSCAFP00000063233	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.993
BDNF	PLCG1	ENSCAFP00000014984	ENSCAFP00000046841	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.601
FRS2	BDNF	ENSCAFP00000000625	ENSCAFP00000014984	Fibroblast growth factor receptor substrate 2.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.644
FRS2	GRB2	ENSCAFP00000000625	ENSCAFP00000049390	Fibroblast growth factor receptor substrate 2.	Growth factor receptor bound protein 2.	0.997
FRS2	NTF4	ENSCAFP00000000625	ENSCAFP00000005718	Fibroblast growth factor receptor substrate 2.	Neurotrophin 4; Belongs to the NGF-beta family.	0.535
FRS2	NTRK2	ENSCAFP00000000625	ENSCAFP00000063233	Fibroblast growth factor receptor substrate 2.	Tyrosine-protein kinase receptor.	0.934
FRS2	SHC1	ENSCAFP00000000625	ENSCAFP00000025262	Fibroblast growth factor receptor substrate 2.	SHC adaptor protein 1.	0.488
GRB2	BDNF	ENSCAFP00000049390	ENSCAFP00000014984	Growth factor receptor bound protein 2.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.582
GRB2	FRS2	ENSCAFP00000049390	ENSCAFP00000000625	Growth factor receptor bound protein 2.	Fibroblast growth factor receptor substrate 2.	0.997
GRB2	NTF4	ENSCAFP00000049390	ENSCAFP00000005718	Growth factor receptor bound protein 2.	Neurotrophin 4; Belongs to the NGF-beta family.	0.543
GRB2	NTRK2	ENSCAFP00000049390	ENSCAFP00000063233	Growth factor receptor bound protein 2.	Tyrosine-protein kinase receptor.	0.930
GRB2	PLCG1	ENSCAFP00000049390	ENSCAFP00000046841	Growth factor receptor bound protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.926
GRB2	PLCG2	ENSCAFP00000049390	ENSCAFP00000029622	Growth factor receptor bound protein 2.	Phosphoinositide phospholipase C.	0.845
GRB2	SHC1	ENSCAFP00000049390	ENSCAFP00000025262	Growth factor receptor bound protein 2.	SHC adaptor protein 1.	0.995
GRB2	SHC2	ENSCAFP00000049390	ENSCAFP00000029189	Growth factor receptor bound protein 2.	Uncharacterized protein.	0.943
GRB2	SHC3	ENSCAFP00000049390	ENSCAFP00000003204	Growth factor receptor bound protein 2.	SHC adaptor protein 3.	0.980