IGF2 protein (Canis lupus familiaris) - STRING interaction network

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gene neighborhood

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Score

IGF2

Insulin like growth factor 2. (304 aa)

Predicted Functional Partners:

IGF2R

0.999

IGF1R

0.999

IGFBP6

0.985

IGFBP3

0.966

IGF1

0.955

GPC3

0.948

IGFBP2

0.936

INSR

0.918

IGFBP4

0.887

IDE

0.855

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GPC3	IGF1R	ENSCAFP00000027825	ENSCAFP00000043796	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Tyrosine-protein kinase receptor.	0.516
GPC3	IGF2	ENSCAFP00000027825	ENSCAFP00000063478	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Insulin like growth factor 2.	0.948
IDE	IGF2	ENSCAFP00000011097	ENSCAFP00000063478	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Insulin like growth factor 2.	0.855
IGF1	IGF1R	ENSCAFP00000058639	ENSCAFP00000043796	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Tyrosine-protein kinase receptor.	0.999
IGF1	IGF2	ENSCAFP00000058639	ENSCAFP00000063478	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor 2.	0.955
IGF1	IGF2R	ENSCAFP00000058639	ENSCAFP00000036713	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor protein.	0.965
IGF1	IGFBP2	ENSCAFP00000058639	ENSCAFP00000021381	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 2.	0.984
IGF1	IGFBP3	ENSCAFP00000058639	ENSCAFP00000018107	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 3.	0.999
IGF1	IGFBP4	ENSCAFP00000058639	ENSCAFP00000023677	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 4.	0.989
IGF1	IGFBP6	ENSCAFP00000058639	ENSCAFP00000052653	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 6.	0.977
IGF1	INSR	ENSCAFP00000058639	ENSCAFP00000038176	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Tyrosine-protein kinase receptor.	0.995
IGF1R	GPC3	ENSCAFP00000043796	ENSCAFP00000027825	Tyrosine-protein kinase receptor.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.516
IGF1R	IGF1	ENSCAFP00000043796	ENSCAFP00000058639	Tyrosine-protein kinase receptor.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.999
IGF1R	IGF2	ENSCAFP00000043796	ENSCAFP00000063478	Tyrosine-protein kinase receptor.	Insulin like growth factor 2.	0.999
IGF1R	IGF2R	ENSCAFP00000043796	ENSCAFP00000036713	Tyrosine-protein kinase receptor.	Cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor protein.	0.906
IGF1R	IGFBP2	ENSCAFP00000043796	ENSCAFP00000021381	Tyrosine-protein kinase receptor.	Insulin like growth factor binding protein 2.	0.595
IGF1R	IGFBP3	ENSCAFP00000043796	ENSCAFP00000018107	Tyrosine-protein kinase receptor.	Insulin like growth factor binding protein 3.	0.774
IGF1R	IGFBP6	ENSCAFP00000043796	ENSCAFP00000052653	Tyrosine-protein kinase receptor.	Insulin like growth factor binding protein 6.	0.689
IGF1R	INSR	ENSCAFP00000043796	ENSCAFP00000038176	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.987
IGF2	GPC3	ENSCAFP00000063478	ENSCAFP00000027825	Insulin like growth factor 2.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.948