RAB22A protein (Canis lupus familiaris) - STRING interaction network

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RAB22A

Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form. (195 aa)

Predicted Functional Partners:

RAB31

0.955

RABGEF1

0.893

APPL1

0.853

APPL2

0.851

RBSN

0.818

RABGGTA

0.772

ARRDC1

0.744

DENND1C

0.682

DENND1B

0.677

CDC16

0.672

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL1	APPL2	ENSCAFP00000011780	ENSCAFP00000002772	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.990
APPL1	RAB22A	ENSCAFP00000011780	ENSCAFP00000064006	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	0.853
APPL1	RAB31	ENSCAFP00000011780	ENSCAFP00000049796	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	RAB31, member RAS oncogene family.	0.878
APPL1	RABGEF1	ENSCAFP00000011780	ENSCAFP00000015865	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	RAB guanine nucleotide exchange factor 1.	0.485
APPL1	RBSN	ENSCAFP00000011780	ENSCAFP00000056036	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Rabenosyn, RAB effector.	0.558
APPL2	APPL1	ENSCAFP00000002772	ENSCAFP00000011780	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.990
APPL2	RAB22A	ENSCAFP00000002772	ENSCAFP00000064006	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	0.851
APPL2	RAB31	ENSCAFP00000002772	ENSCAFP00000049796	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB31, member RAS oncogene family.	0.851
APPL2	RBSN	ENSCAFP00000002772	ENSCAFP00000056036	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Rabenosyn, RAB effector.	0.495
ARRDC1	RAB22A	ENSCAFP00000028666	ENSCAFP00000064006	Arrestin domain containing 1.	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	0.744
CDC16	RAB22A	ENSCAFP00000009724	ENSCAFP00000064006	Cell division cycle 16.	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	0.672
DENND1B	DENND1C	ENSCAFP00000016716	ENSCAFP00000027498	DENN domain containing 1B.	DENN domain containing 1C.	0.434
DENND1B	RAB22A	ENSCAFP00000016716	ENSCAFP00000064006	DENN domain containing 1B.	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	0.677
DENND1B	RABGEF1	ENSCAFP00000016716	ENSCAFP00000015865	DENN domain containing 1B.	RAB guanine nucleotide exchange factor 1.	0.528
DENND1C	DENND1B	ENSCAFP00000027498	ENSCAFP00000016716	DENN domain containing 1C.	DENN domain containing 1B.	0.434
DENND1C	RAB22A	ENSCAFP00000027498	ENSCAFP00000064006	DENN domain containing 1C.	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	0.682
RAB22A	APPL1	ENSCAFP00000064006	ENSCAFP00000011780	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.853
RAB22A	APPL2	ENSCAFP00000064006	ENSCAFP00000002772	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.851
RAB22A	ARRDC1	ENSCAFP00000064006	ENSCAFP00000028666	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	Arrestin domain containing 1.	0.744
RAB22A	CDC16	ENSCAFP00000064006	ENSCAFP00000009724	Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.	Cell division cycle 16.	0.672

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