STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3646 aa)    
Predicted Functional Partners:
GCC2
GRIP and coiled-coil domain containing 2.
    
 
 0.721
KCNK15
Potassium two pore domain channel subfamily K member 15; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
  
 0.715
OIT3
Oncoprotein induced transcript 3.
    
 
 0.694
ANGPT2
Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).
   
 
 0.663
BST1
Bone marrow stromal cell antigen 1.
   
  
 0.645
ADAMTS14
ADAM metallopeptidase with thrombospondin type 1 motif 14.
   
 
 0.578
RGS18
Regulator of G protein signaling 18.
   
 
 0.535
ENSCAFP00000059460
Pep_M12B_propep domain-containing protein.
   
 
 0.525
ZNF175
Zinc finger protein 175.
    
 
 0.521
BCO1
Beta-carotene oxygenase 1.
      
 0.515
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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