STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNAB2Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (436 aa)    
Predicted Functional Partners:
KCNA2
Potassium voltage-gated channel subfamily A member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form funct [...]
   
 0.892
KCNC1
Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family.
   
 0.814
KCNA5
Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.
   
 0.812
KCNA1
Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family.
   
 0.811
KCNH1
Potassium voltage-gated channel subfamily H member 1.
    
 0.810
KCNG4
Potassium voltage-gated channel modifier subfamily G member 4; Belongs to the potassium channel family.
   
 0.802
KCNG1
Potassium voltage-gated channel modifier subfamily G member 1; Belongs to the potassium channel family.
   
 0.797
KCNA4
Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family.
   
 0.792
KCNA10
Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family.
   
 0.773
KCNA7
Potassium voltage-gated channel subfamily A member 7; Belongs to the potassium channel family.
   
 0.768
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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