STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN20Protein tyrosine phosphatase non-receptor type 20. (588 aa)    
Predicted Functional Partners:
FAM72A
Uncharacterized protein.
      
 0.873
ARHGAP11A
Rho GTPase activating protein 11A.
      
 0.872
ARHGEF5
Rho guanine nucleotide exchange factor 5.
      
 0.850
BOLA2B
Uncharacterized protein; Belongs to the BolA/IbaG family.
      
 0.747
SLX1A
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
      
 0.709
FAM81A
Family with sequence similarity 81 member A.
      
 0.692
LMBR1L
Limb development membrane protein 1 like; Belongs to the LIMR family.
    
 
 0.675
CD8B
Ig-like domain-containing protein.
   
  
 0.658
TOR2A
Torsin.
      
 0.632
FCGR1A
Uncharacterized protein.
   
 
 0.609
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.