STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (513 aa)    
Predicted Functional Partners:
MAML1
Mastermind like transcriptional coactivator 1.
   
 0.999
NOTCH1
Notch receptor 1.
    
 0.998
MAML3
Mastermind like transcriptional coactivator 3.
   
 0.995
NOTCH3
Notch receptor 3.
    
 0.993
NOTCH2
Notch receptor 2.
    
 0.986
MAML2
Mastermind like transcriptional coactivator 2.
   
 0.973
NCOR2
Nuclear receptor corepressor 2.
    
 0.960
EP300
E1A binding protein p300.
    
 0.941
PTPN9
SIN3 transcription regulator family member A.
   
 0.938
HDAC1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 0.932
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (28%) [HD]