node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | KAT5 | ENSCAFP00000035996 | ENSCAFP00000064911 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.955 |
ATM | TRRAP | ENSCAFP00000035996 | ENSCAFP00000045167 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.504 |
ATP2A1 | ATP2A2 | ENSCAFP00000042475 | ENSCAFP00000050835 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | 0.909 |
ATP2A1 | ATP2A3 | ENSCAFP00000042475 | ENSCAFP00000020631 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.904 |
ATP2A1 | KAT5 | ENSCAFP00000042475 | ENSCAFP00000064911 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.901 |
ATP2A2 | ATP2A1 | ENSCAFP00000050835 | ENSCAFP00000042475 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.909 |
ATP2A2 | ATP2A3 | ENSCAFP00000050835 | ENSCAFP00000020631 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.904 |
ATP2A2 | ITPR1 | ENSCAFP00000050835 | ENSCAFP00000008870 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Inositol 1,4,5-trisphosphate receptor type 1. | 0.430 |
ATP2A2 | KAT5 | ENSCAFP00000050835 | ENSCAFP00000064911 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.901 |
ATP2A3 | ATP2A1 | ENSCAFP00000020631 | ENSCAFP00000042475 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.904 |
ATP2A3 | ATP2A2 | ENSCAFP00000020631 | ENSCAFP00000050835 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | 0.904 |
ATP2A3 | GRM1 | ENSCAFP00000020631 | ENSCAFP00000000479 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Glutamate metabotropic receptor 1. | 0.427 |
ATP2A3 | KAT5 | ENSCAFP00000020631 | ENSCAFP00000064911 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.900 |
ATXN1 | ATXN1L | ENSCAFP00000037698 | ENSCAFP00000032624 | Ataxin 1. | Ataxin 1 like. | 0.923 |
ATXN1 | KAT5 | ENSCAFP00000037698 | ENSCAFP00000064911 | Ataxin 1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.929 |
ATXN1L | ATXN1 | ENSCAFP00000032624 | ENSCAFP00000037698 | Ataxin 1 like. | Ataxin 1. | 0.923 |
ATXN1L | KAT5 | ENSCAFP00000032624 | ENSCAFP00000064911 | Ataxin 1 like. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.913 |
GRM1 | ATP2A3 | ENSCAFP00000000479 | ENSCAFP00000020631 | Glutamate metabotropic receptor 1. | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.427 |
GRM1 | ITPR1 | ENSCAFP00000000479 | ENSCAFP00000008870 | Glutamate metabotropic receptor 1. | Inositol 1,4,5-trisphosphate receptor type 1. | 0.627 |
GRM1 | KAT5 | ENSCAFP00000000479 | ENSCAFP00000064911 | Glutamate metabotropic receptor 1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.900 |