OR7G2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

OR7G2

Olfactory receptor. (315 aa)

Predicted Functional Partners:

POLR2C

0.786

NACC1

0.712

GNAL

0.687

GNB1

0.682

ARRB2

0.679

ARRB1

0.679

GNG13

0.677

GRK2

0.674

GRK3

0.674

PRKACB

0.658

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSCAFP00000056636	ENSCAFP00000053738	Arrestin beta 1.	Arrestin beta 2.	0.903
ARRB1	GRK2	ENSCAFP00000056636	ENSCAFP00000017324	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.966
ARRB1	GRK3	ENSCAFP00000056636	ENSCAFP00000059736	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.900
ARRB1	OR7G2	ENSCAFP00000056636	ENSCAFP00000065056	Arrestin beta 1.	Olfactory receptor.	0.679
ARRB1	PRKACB	ENSCAFP00000056636	ENSCAFP00000030135	Arrestin beta 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.512
ARRB2	ARRB1	ENSCAFP00000053738	ENSCAFP00000056636	Arrestin beta 2.	Arrestin beta 1.	0.903
ARRB2	GRK2	ENSCAFP00000053738	ENSCAFP00000017324	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.965
ARRB2	GRK3	ENSCAFP00000053738	ENSCAFP00000059736	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.900
ARRB2	OR7G2	ENSCAFP00000053738	ENSCAFP00000065056	Arrestin beta 2.	Olfactory receptor.	0.679
ARRB2	PRKACB	ENSCAFP00000053738	ENSCAFP00000030135	Arrestin beta 2.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.512
GNAL	GNB1	ENSCAFP00000053739	ENSCAFP00000028342	G protein subunit alpha L.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.970
GNAL	GNG13	ENSCAFP00000053739	ENSCAFP00000029000	G protein subunit alpha L.	G protein subunit gamma 13.	0.954
GNAL	OR7G2	ENSCAFP00000053739	ENSCAFP00000065056	G protein subunit alpha L.	Olfactory receptor.	0.687
GNB1	GNAL	ENSCAFP00000028342	ENSCAFP00000053739	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit alpha L.	0.970
GNB1	GNG13	ENSCAFP00000028342	ENSCAFP00000029000	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit gamma 13.	0.960
GNB1	GRK2	ENSCAFP00000028342	ENSCAFP00000017324	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.990
GNB1	GRK3	ENSCAFP00000028342	ENSCAFP00000059736	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.598
GNB1	OR7G2	ENSCAFP00000028342	ENSCAFP00000065056	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Olfactory receptor.	0.682
GNB1	PRKACB	ENSCAFP00000028342	ENSCAFP00000030135	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.730
GNG13	GNAL	ENSCAFP00000029000	ENSCAFP00000053739	G protein subunit gamma 13.	G protein subunit alpha L.	0.954

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.745

expected number of edges:

13

PPI enrichment p-value:

0.0636

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008236

Serine-type peptidase activity

3 of 18

1.57

0.77

0.0272

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

3 of 30

1.35

0.63

0.0440

GO:0016787

Hydrolase activity

8 of 398

0.65

0.41

0.0272

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

3 of 35

1.28

0.62

0.0435

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1463

Mixed, incl. PGBD superfamily, and NlpC/P60 family

5 of 7

2.2

3.23

2.68e-07

CL:1396

Mixed, incl. Cell division, and Beta-lactamase/transpeptidase-like

6 of 68

1.3

1.41

4.56e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01040

Biosynthesis of unsaturated fatty acids

2 of 3

2.17

0.94

0.0176

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

5 of 73

1.19

0.95

0.0021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13472

GDSL-like Lipase/Acylhydrolase family

2 of 2

2.35

0.77

0.0393

PF01471

Putative peptidoglycan binding domain

2 of 3

2.17

0.76

0.0393

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