Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KLK2Arginine esterase; This serine protease is found in dog seminal plasma, its exact physiological function is not known. (389 aa)    
Predicted Functional Partners:
KNG1
Kininogen 1.
   
 
 0.824
AR
Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
    
 
 0.791
ENPEP
Aminopeptidase.
    
 0.747
PRCP
Prolylcarboxypeptidase.
     
 0.721
ACE2
Angiotensin-converting enzyme.
   
 0.705
ACP3
Acid phosphatase, prostate; Belongs to the histidine acid phosphatase family.
   
 
 0.665
F7
Coagulation factor X.
  
   0.593
ELANE
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
 
 0.588
ENSCAFP00000058636
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
  
  0.561
PRSS41
Serine protease 41.
  
 
   0.557
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.