STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRAMD2AGRAM domain containing 2A. (579 aa)    
Predicted Functional Partners:
VMO1
Vitelline membrane outer layer 1 homolog.
    
 
 0.525
TGM7
Transglutaminase 7.
      
 0.515
DCST1
DC-STAMP domain containing 1.
      
 0.499
TECRL
Trans-2,3-enoyl-CoA reductase like.
      
 0.491
ALDH8A1
Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family.
      
 0.483
JAML
Junction adhesion molecule like.
    
 
 0.480
SCN2B
Sodium channel subunit beta-2; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
    
 
 0.480
ACOT12
Acyl-CoA thioesterase 12.
      
 0.457
CRYBA2
Crystallin beta A2; Belongs to the beta/gamma-crystallin family.
      
 0.450
UBE2Q1
Ubiquitin conjugating enzyme E2 Q1.
   
  
 0.400
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.