MAP3K4 protein (Canis lupus familiaris) - STRING interaction network

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Score

MAP3K4

Mitogen-activated protein kinase kinase kinase 4. (1679 aa)

Predicted Functional Partners:

GADD45B

0.964

MAP2K3

0.953

MAP2K6

0.949

GADD45A

0.941

MAP2K5

0.684

MAP2K2

0.677

MAP2K1

0.674

PLBD1

0.591

PRDM15

0.591

COPZ2

0.591

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COPZ2	MAP3K4	ENSCAFP00000062825	ENSCAFP00000065786	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	Mitogen-activated protein kinase kinase kinase 4.	0.591
COPZ2	PLBD1	ENSCAFP00000062825	ENSCAFP00000019292	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	Phospholipase B-like; Putative phospholipase.	0.647
COPZ2	PRDM15	ENSCAFP00000062825	ENSCAFP00000040617	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	PR/SET domain 15.	0.647
GADD45A	GADD45B	ENSCAFP00000046669	ENSCAFP00000028654	Growth arrest and DNA damage inducible alpha.	Growth arrest and DNA damage inducible beta.	0.902
GADD45A	MAP3K4	ENSCAFP00000046669	ENSCAFP00000065786	Growth arrest and DNA damage inducible alpha.	Mitogen-activated protein kinase kinase kinase 4.	0.941
GADD45B	GADD45A	ENSCAFP00000028654	ENSCAFP00000046669	Growth arrest and DNA damage inducible beta.	Growth arrest and DNA damage inducible alpha.	0.902
GADD45B	MAP3K4	ENSCAFP00000028654	ENSCAFP00000065786	Growth arrest and DNA damage inducible beta.	Mitogen-activated protein kinase kinase kinase 4.	0.964
MAP2K1	MAP2K2	ENSCAFP00000045279	ENSCAFP00000043510	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).	0.905
MAP2K1	MAP3K4	ENSCAFP00000045279	ENSCAFP00000065786	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 4.	0.674
MAP2K2	MAP2K1	ENSCAFP00000043510	ENSCAFP00000045279	Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.905
MAP2K2	MAP3K4	ENSCAFP00000043510	ENSCAFP00000065786	Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).	Mitogen-activated protein kinase kinase kinase 4.	0.677
MAP2K3	MAP2K6	ENSCAFP00000061410	ENSCAFP00000059059	Mitogen-activated protein kinase kinase 3.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.901
MAP2K3	MAP3K4	ENSCAFP00000061410	ENSCAFP00000065786	Mitogen-activated protein kinase kinase 3.	Mitogen-activated protein kinase kinase kinase 4.	0.953
MAP2K5	MAP3K4	ENSCAFP00000040243	ENSCAFP00000065786	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 4.	0.684
MAP2K6	MAP2K3	ENSCAFP00000059059	ENSCAFP00000061410	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 3.	0.901
MAP2K6	MAP3K4	ENSCAFP00000059059	ENSCAFP00000065786	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 4.	0.949
MAP3K4	COPZ2	ENSCAFP00000065786	ENSCAFP00000062825	Mitogen-activated protein kinase kinase kinase 4.	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	0.591
MAP3K4	GADD45A	ENSCAFP00000065786	ENSCAFP00000046669	Mitogen-activated protein kinase kinase kinase 4.	Growth arrest and DNA damage inducible alpha.	0.941
MAP3K4	GADD45B	ENSCAFP00000065786	ENSCAFP00000028654	Mitogen-activated protein kinase kinase kinase 4.	Growth arrest and DNA damage inducible beta.	0.964
MAP3K4	MAP2K1	ENSCAFP00000065786	ENSCAFP00000045279	Mitogen-activated protein kinase kinase kinase 4.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.674