STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GUCA2BGuanylate cyclase activator 2B. (123 aa)    
Predicted Functional Partners:
GUCY2C
Guanylate cyclase.
   
 
 0.901
PDZD3
PDZ domain containing 3.
   
  
 0.805
GUCA2A
Guanylate cyclase activator 2A.
   
  
 0.776
FANCL
FA complementation group L.
      
 0.769
AQP4
Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.676
SLC46A2
Thymic stromal cotransporter homolog; May act as a transporter (By similarity). May be involved in establishing and maintaining the luminal fluid microenvironment.
      
 0.675
ARHGEF25
Rho guanine nucleotide exchange factor 25.
      
 0.650
RAD18
RAD18 E3 ubiquitin protein ligase.
      
 0.637
RAD17
RAD17 checkpoint clamp loader component.
      
 0.637
NEDD4L
NEDD4 like E3 ubiquitin protein ligase.
      
 0.567
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.