SIM1 protein (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SIM1

SIM bHLH transcription factor 1. (789 aa)

Predicted Functional Partners:

MC4R

0.879

ARNT2

0.781

POMC

0.758

TRH

0.758

ARNT

0.715

MCHR2

0.708

DBX1

0.630

PCSK1

0.615

LEP

0.609

TLX3

0.565

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNT	SIM1	ENSCAFP00000018081	ENSCAFP00000065936	Aryl hydrocarbon receptor nuclear translocator.	SIM bHLH transcription factor 1.	0.715
ARNT2	SIM1	ENSCAFP00000062321	ENSCAFP00000065936	Aryl hydrocarbon receptor nuclear translocator 2.	SIM bHLH transcription factor 1.	0.781
DBX1	SIM1	ENSCAFP00000014415	ENSCAFP00000065936	Developing brain homeobox 1.	SIM bHLH transcription factor 1.	0.630
LEP	MC4R	ENSCAFP00000002433	ENSCAFP00000000126	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Melanocortin-4 receptor.	0.859
LEP	PCSK1	ENSCAFP00000002433	ENSCAFP00000011663	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.538
LEP	POMC	ENSCAFP00000002433	ENSCAFP00000006163	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Proopiomelanocortin.	0.996
LEP	SIM1	ENSCAFP00000002433	ENSCAFP00000065936	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	SIM bHLH transcription factor 1.	0.609
LEP	TRH	ENSCAFP00000002433	ENSCAFP00000056224	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Thyrotropin releasing hormone.	0.751
MC4R	LEP	ENSCAFP00000000126	ENSCAFP00000002433	Melanocortin-4 receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.859
MC4R	PCSK1	ENSCAFP00000000126	ENSCAFP00000011663	Melanocortin-4 receptor.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.717
MC4R	POMC	ENSCAFP00000000126	ENSCAFP00000006163	Melanocortin-4 receptor.	Proopiomelanocortin.	0.998
MC4R	SIM1	ENSCAFP00000000126	ENSCAFP00000065936	Melanocortin-4 receptor.	SIM bHLH transcription factor 1.	0.879
MC4R	TRH	ENSCAFP00000000126	ENSCAFP00000056224	Melanocortin-4 receptor.	Thyrotropin releasing hormone.	0.746
MCHR2	POMC	ENSCAFP00000005250	ENSCAFP00000006163	Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family.	Proopiomelanocortin.	0.556
MCHR2	SIM1	ENSCAFP00000005250	ENSCAFP00000065936	Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family.	SIM bHLH transcription factor 1.	0.708
MCHR2	TRH	ENSCAFP00000005250	ENSCAFP00000056224	Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family.	Thyrotropin releasing hormone.	0.678
PCSK1	LEP	ENSCAFP00000011663	ENSCAFP00000002433	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.538
PCSK1	MC4R	ENSCAFP00000011663	ENSCAFP00000000126	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	Melanocortin-4 receptor.	0.717
PCSK1	POMC	ENSCAFP00000011663	ENSCAFP00000006163	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	Proopiomelanocortin.	0.897
PCSK1	SIM1	ENSCAFP00000011663	ENSCAFP00000065936	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	SIM bHLH transcription factor 1.	0.615