STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APLP1Amyloid beta precursor like protein 1. (752 aa)    
Predicted Functional Partners:
CNTN5
Contactin 5.
   
 
 0.812
NCSTN
Ncstrn_small domain-containing protein.
   
 
 0.754
BACE1
Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
   
 
 0.717
HPX
Amyloid beta precursor protein binding family B member 1.
   
 
 0.712
NPR3
Natriuretic peptide receptor 3.
      
 0.695
BACE2
Beta-secretase 2; Belongs to the peptidase A1 family.
    
 
 0.653
CLIP3
CAP-Gly domain containing linker protein 3.
   
  
 0.640
SORL1
Sortilin related receptor 1.
    
 
 0.638
APBB2
Amyloid beta precursor protein binding family B member 2.
    
 
 0.617
PSEN1
Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...]
   
 
 0.612
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.