STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CGASCyclic GMP-AMP synthase. (501 aa)    
Predicted Functional Partners:
DDX41
DEAD-box helicase 41.
      
 0.894
IRF3
Interferon regulatory factor 3.
      
 0.863
TBK1
TANK binding kinase 1.
      
 0.855
MAVS
Mitochondrial antiviral signaling protein.
      
 0.799
STING1
Transmembrane protein 173.
    
 
 0.760
MNDA
Myeloid cell nuclear differentiation antigen.
    
 
 0.676
TLR3
Toll like receptor 3; Belongs to the Toll-like receptor family.
      
 0.674
IFNB1
Interferon-beta.
      
 0.669
TLR9-2
Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).
      
 0.656
ISG15
ISG15 ubiquitin like modifier.
      
 0.636
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.