MECOM protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

MECOM

MDS1 and EVI1 complex locus. (1239 aa)

Predicted Functional Partners:

CTBP2

0.937

RUNX1

0.918

HDAC1

0.914

HDAC2

0.914

MAPK10

0.904

MAPK8

0.904

MAPK9

0.902

RBBP7

0.777

ENSCAFP00000058271

0.777

SUZ12

0.610

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTBP2	HDAC1	ENSCAFP00000051395	ENSCAFP00000036819	C-terminal binding protein 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.907
CTBP2	HDAC2	ENSCAFP00000051395	ENSCAFP00000042408	C-terminal binding protein 2.	Histone deacetylase 2.	0.876
CTBP2	MECOM	ENSCAFP00000051395	ENSCAFP00000066483	C-terminal binding protein 2.	MDS1 and EVI1 complex locus.	0.937
CTBP2	RUNX1	ENSCAFP00000051395	ENSCAFP00000014111	C-terminal binding protein 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.913
ENSCAFP00000058271	HDAC1	ENSCAFP00000058271	ENSCAFP00000036819	WD_REPEATS_REGION domain-containing protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.869
ENSCAFP00000058271	HDAC2	ENSCAFP00000058271	ENSCAFP00000042408	WD_REPEATS_REGION domain-containing protein.	Histone deacetylase 2.	0.869
ENSCAFP00000058271	MECOM	ENSCAFP00000058271	ENSCAFP00000066483	WD_REPEATS_REGION domain-containing protein.	MDS1 and EVI1 complex locus.	0.777
ENSCAFP00000058271	RBBP7	ENSCAFP00000058271	ENSCAFP00000018764	WD_REPEATS_REGION domain-containing protein.	RB binding protein 7, chromatin remodeling factor.	0.930
ENSCAFP00000058271	SUZ12	ENSCAFP00000058271	ENSCAFP00000027313	WD_REPEATS_REGION domain-containing protein.	SUZ12 polycomb repressive complex 2 subunit.	0.949
HDAC1	CTBP2	ENSCAFP00000036819	ENSCAFP00000051395	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	C-terminal binding protein 2.	0.907
HDAC1	ENSCAFP00000058271	ENSCAFP00000036819	ENSCAFP00000058271	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	WD_REPEATS_REGION domain-containing protein.	0.869
HDAC1	HDAC2	ENSCAFP00000036819	ENSCAFP00000042408	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 2.	0.958
HDAC1	MECOM	ENSCAFP00000036819	ENSCAFP00000066483	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	MDS1 and EVI1 complex locus.	0.914
HDAC1	RBBP7	ENSCAFP00000036819	ENSCAFP00000018764	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	RB binding protein 7, chromatin remodeling factor.	0.944
HDAC1	RUNX1	ENSCAFP00000036819	ENSCAFP00000014111	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.923
HDAC1	SUZ12	ENSCAFP00000036819	ENSCAFP00000027313	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	SUZ12 polycomb repressive complex 2 subunit.	0.529
HDAC2	CTBP2	ENSCAFP00000042408	ENSCAFP00000051395	Histone deacetylase 2.	C-terminal binding protein 2.	0.876
HDAC2	ENSCAFP00000058271	ENSCAFP00000042408	ENSCAFP00000058271	Histone deacetylase 2.	WD_REPEATS_REGION domain-containing protein.	0.869
HDAC2	HDAC1	ENSCAFP00000042408	ENSCAFP00000036819	Histone deacetylase 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.958
HDAC2	MECOM	ENSCAFP00000042408	ENSCAFP00000066483	Histone deacetylase 2.	MDS1 and EVI1 complex locus.	0.914