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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK5R2Cyclin-dependent kinase 5 activator. (301 aa)    
Predicted Functional Partners:
CDK5
Cyclin-dependent-like kinase 5 isoform X3; Belongs to the protein kinase superfamily.
    
 0.987
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
     
 0.706
CRYBA2
Beta-crystallin A2 isoform X1; Belongs to the beta/gamma-crystallin family.
      
 0.567
ENSVVUP00000004522
annotation not available
   
  0.557
MET
Hepatocyte growth factor receptor isoform X1.
   
  0.557
MST1R
Macrophage-stimulating protein receptor isoform X3.
   
  0.557
TP73
Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
     
 0.509
DNAJC5B
dnaJ homolog subfamily C member 5B.
      
 0.505
PLXNA3
plexin-A3 isoform X1.
   
 
 0.471
PLXNA4
plexin-A4.
   
 
  0.469
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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