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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NR1D1Nuclear receptor subfamily 1 group D member 1. (617 aa)    
Predicted Functional Partners:
NCOR1
Nuclear receptor corepressor 1 isoform X5.
    
 0.945
NCOR2
Nuclear receptor corepressor 2 isoform X9.
    
 0.899
CRY1
Cryptochrome-1.
      
 0.848
GPS2
G protein pathway suppressor 2.
    
 0.817
CRY2
Cryptochrome-2.
      
 0.767
ARNTL
Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3.
     
 0.656
NFIL3
Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]
   
 
 0.631
ENSVVUP00000034241
annotation not available
   
 
 0.631
HDAC3
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
    
 0.606
CLOCK
Circadian locomoter output cycles protein kaput isoform X1.
     
 0.578
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.