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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPRKReceptor-type tyrosine-protein phosphatase kappa isoform X8. (1430 aa)    
Predicted Functional Partners:
WAC
WW domain-containing adapter protein with coiled-coil isoform X2.
   
  
 0.624
KIAA0408
Uncharacterized protein KIAA0408 homolog.
      
 0.623
PTK7
Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.566
PKP2
Plakophilin-2.
   
 
 0.541
KIF20A
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.524
GRXCR1
Glutaredoxin domain-containing cysteine-rich protein 1.
   
  
 0.520
PDIK1L
Serine/threonine-protein kinase PDIK1L; Belongs to the protein kinase superfamily.
      
 0.518
SH3BGRL2
SH3 domain-binding glutamic acid-rich-like protein 2.
   
  
 0.514
ITGAV
Integrin alpha-V; Belongs to the integrin alpha chain family.
    
 0.508
EGFR
Receptor protein-tyrosine kinase.
   
 0.502
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.