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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X1. (343 aa)    
Predicted Functional Partners:
HMGCS2
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
     
 0.969
AUH
methylglutaconyl-CoA hydratase, mitochondrial isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 
 0.967
HMGCS1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
     
 0.963
OXCT1
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial.
  
 
 0.951
ACAT1
acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.949
BDH1
D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.943
ACAT2
acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.942
AACS
acetoacetyl-CoA synthetase.
  
 
 0.942
ACAA1
3-ketoacyl-CoA thiolase, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.941
HADHB
Trifunctional enzyme subunit beta, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.937
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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