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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL6RInterleukin-6 receptor subunit alpha. (452 aa)    
Predicted Functional Partners:
IL6
Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]
   
 0.999
STAT3
Signal transducer and activator of transcription.
   
 0.843
IL6ST
Interleukin-6 receptor subunit beta isoform X1.
   
0.800
SOCS3
Suppressor of cytokine signaling 3.
   
 
 0.761
JAK2
Tyrosine-protein kinase.
   
 0.710
IL12RB2
Interleukin-12 receptor subunit beta-2.
   
0.702
JAK1
Tyrosine-protein kinase.
   
 0.682
TYK2
Tyrosine-protein kinase.
   
 0.682
IL27RA
Interleukin-27 receptor subunit alpha.
   
 0.668
TNF
Tumor necrosis factor; Belongs to the tumor necrosis factor family.
   
 
 0.633
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.