BABAM2 protein (Vulpes vulpes) - STRING interaction network

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Score

BABAM2

BRISC and BRCA1-A complex member 2 isoform X2. (497 aa)

Predicted Functional Partners:

BABAM1

0.999

ABRAXAS1

0.998

UIMC1

0.997

ABRAXAS2

0.994

LOC112908355

0.989

BRCC3

0.989

BRCA1

0.838

SHMT2

0.752

BARD1

0.751

ATM

0.672

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABRAXAS1	ATM	ENSVVUP00000021307	ENSVVUP00000020826	BRCA1-A complex subunit Abraxas 1 isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.556
ABRAXAS1	BABAM1	ENSVVUP00000021307	ENSVVUP00000022021	BRCA1-A complex subunit Abraxas 1 isoform X1.	BRISC and BRCA1-A complex member 1.	0.999
ABRAXAS1	BABAM2	ENSVVUP00000021307	ENSVVUP00000002379	BRCA1-A complex subunit Abraxas 1 isoform X1.	BRISC and BRCA1-A complex member 2 isoform X2.	0.998
ABRAXAS1	BARD1	ENSVVUP00000021307	ENSVVUP00000012347	BRCA1-A complex subunit Abraxas 1 isoform X1.	BRCA1-associated RING domain protein 1.	0.985
ABRAXAS1	BRCA1	ENSVVUP00000021307	ENSVVUP00000033145	BRCA1-A complex subunit Abraxas 1 isoform X1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.998
ABRAXAS1	BRCC3	ENSVVUP00000021307	ENSVVUP00000028281	BRCA1-A complex subunit Abraxas 1 isoform X1.	Lys-63-specific deubiquitinase BRCC36.	0.990
ABRAXAS1	LOC112908355	ENSVVUP00000021307	ENSVVUP00000013179	BRCA1-A complex subunit Abraxas 1 isoform X1.	LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like.	0.990
ABRAXAS1	UIMC1	ENSVVUP00000021307	ENSVVUP00000001565	BRCA1-A complex subunit Abraxas 1 isoform X1.	Ubiquitin interaction motif containing 1.	0.998
ABRAXAS2	BABAM1	ENSVVUP00000007933	ENSVVUP00000022021	BRISC complex subunit Abraxas 2.	BRISC and BRCA1-A complex member 1.	0.991
ABRAXAS2	BABAM2	ENSVVUP00000007933	ENSVVUP00000002379	BRISC complex subunit Abraxas 2.	BRISC and BRCA1-A complex member 2 isoform X2.	0.994
ABRAXAS2	BRCC3	ENSVVUP00000007933	ENSVVUP00000028281	BRISC complex subunit Abraxas 2.	Lys-63-specific deubiquitinase BRCC36.	0.975
ABRAXAS2	LOC112908355	ENSVVUP00000007933	ENSVVUP00000013179	BRISC complex subunit Abraxas 2.	LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like.	0.975
ABRAXAS2	SHMT2	ENSVVUP00000007933	ENSVVUP00000024712	BRISC complex subunit Abraxas 2.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.661
ABRAXAS2	UIMC1	ENSVVUP00000007933	ENSVVUP00000001565	BRISC complex subunit Abraxas 2.	Ubiquitin interaction motif containing 1.	0.404
ATM	ABRAXAS1	ENSVVUP00000020826	ENSVVUP00000021307	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1-A complex subunit Abraxas 1 isoform X1.	0.556
ATM	BABAM1	ENSVVUP00000020826	ENSVVUP00000022021	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRISC and BRCA1-A complex member 1.	0.616
ATM	BABAM2	ENSVVUP00000020826	ENSVVUP00000002379	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRISC and BRCA1-A complex member 2 isoform X2.	0.672
ATM	BARD1	ENSVVUP00000020826	ENSVVUP00000012347	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1-associated RING domain protein 1.	0.922
ATM	BRCA1	ENSVVUP00000020826	ENSVVUP00000033145	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.996
ATM	BRCC3	ENSVVUP00000020826	ENSVVUP00000028281	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Lys-63-specific deubiquitinase BRCC36.	0.511