HIPK2 protein (Vulpes vulpes) - STRING interaction network

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Score

HIPK2

Homeodomain-interacting protein kinase 2 isoform X1. (1365 aa)

Predicted Functional Partners:

TP53

0.991

PIN1

0.928

MECP2

0.926

RASSF5

0.909

DCAF7

0.894

CBFB

0.795

SIAH1

0.763

SMAD3

0.709

TP53INP1

0.687

ENSVVUP00000003930

0.676

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBFB	HIPK2	ENSVVUP00000015202	ENSVVUP00000003065	Core-binding factor subunit beta isoform X2.	Homeodomain-interacting protein kinase 2 isoform X1.	0.795
DCAF7	HIPK2	ENSVVUP00000007665	ENSVVUP00000003065	DDB1- and CUL4-associated factor 7.	Homeodomain-interacting protein kinase 2 isoform X1.	0.894
ENSVVUP00000003930	HIPK2	ENSVVUP00000003930	ENSVVUP00000003065	annotation not available	Homeodomain-interacting protein kinase 2 isoform X1.	0.676
ENSVVUP00000003930	TP53	ENSVVUP00000003930	ENSVVUP00000039187	annotation not available	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.674
HIPK2	CBFB	ENSVVUP00000003065	ENSVVUP00000015202	Homeodomain-interacting protein kinase 2 isoform X1.	Core-binding factor subunit beta isoform X2.	0.795
HIPK2	DCAF7	ENSVVUP00000003065	ENSVVUP00000007665	Homeodomain-interacting protein kinase 2 isoform X1.	DDB1- and CUL4-associated factor 7.	0.894
HIPK2	ENSVVUP00000003930	ENSVVUP00000003065	ENSVVUP00000003930	Homeodomain-interacting protein kinase 2 isoform X1.	annotation not available	0.676
HIPK2	MECP2	ENSVVUP00000003065	ENSVVUP00000041582	Homeodomain-interacting protein kinase 2 isoform X1.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.926
HIPK2	PIN1	ENSVVUP00000003065	ENSVVUP00000003866	Homeodomain-interacting protein kinase 2 isoform X1.	Peptidyl-prolyl cis-trans isomerase.	0.928
HIPK2	RASSF5	ENSVVUP00000003065	ENSVVUP00000018376	Homeodomain-interacting protein kinase 2 isoform X1.	Ras association domain-containing protein 5.	0.909
HIPK2	SIAH1	ENSVVUP00000003065	ENSVVUP00000021984	Homeodomain-interacting protein kinase 2 isoform X1.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.763
HIPK2	SMAD3	ENSVVUP00000003065	ENSVVUP00000019777	Homeodomain-interacting protein kinase 2 isoform X1.	Mothers against decapentaplegic homolog.	0.709
HIPK2	TP53	ENSVVUP00000003065	ENSVVUP00000039187	Homeodomain-interacting protein kinase 2 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.991
HIPK2	TP53INP1	ENSVVUP00000003065	ENSVVUP00000003972	Homeodomain-interacting protein kinase 2 isoform X1.	Tumor protein p53-inducible nuclear protein 1 isoform X1.	0.687
MECP2	HIPK2	ENSVVUP00000041582	ENSVVUP00000003065	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	Homeodomain-interacting protein kinase 2 isoform X1.	0.926
PIN1	HIPK2	ENSVVUP00000003866	ENSVVUP00000003065	Peptidyl-prolyl cis-trans isomerase.	Homeodomain-interacting protein kinase 2 isoform X1.	0.928
PIN1	TP53	ENSVVUP00000003866	ENSVVUP00000039187	Peptidyl-prolyl cis-trans isomerase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.796
RASSF5	HIPK2	ENSVVUP00000018376	ENSVVUP00000003065	Ras association domain-containing protein 5.	Homeodomain-interacting protein kinase 2 isoform X1.	0.909
SIAH1	HIPK2	ENSVVUP00000021984	ENSVVUP00000003065	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Homeodomain-interacting protein kinase 2 isoform X1.	0.763
SMAD3	HIPK2	ENSVVUP00000019777	ENSVVUP00000003065	Mothers against decapentaplegic homolog.	Homeodomain-interacting protein kinase 2 isoform X1.	0.709