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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CFHR5Complement factor H-related protein 5 isoform X1. (570 aa)    
Predicted Functional Partners:
LOC112921719
Complement factor H-related protein 2-like.
     
 
0.900
FGA
Fibrinogen alpha chain.
   
 0.808
DGKE
Diacylglycerol kinase.
      
 0.697
CFB
Complement factor B; Belongs to the peptidase S1 family.
   
 0.676
C8A
Complement component C8 alpha chain.
   
  
 0.674
HGD
Homogentisate 1,2-dioxygenase.
   
  
 0.662
FGG
Fibrinogen gamma chain isoform X2.
   
 0.657
EPB42
Erythrocyte membrane protein band 4.2.
    
 0.654
FGB
Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...]
   
 0.612
MMACHC
Methylmalonic aciduria and homocystinuria type C protein.
    
 
 0.607
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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