Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IGF2Insulin-like growth factor II isoform X2. (238 aa)    
Predicted Functional Partners:
IGF1R
Tyrosine-protein kinase receptor.
    
 0.990
IGFBP4
Insulin-like growth factor-binding protein 4.
    
 0.986
INSR
Tyrosine-protein kinase receptor.
    
 0.984
ENSVVUP00000041494
annotation not available
   
 0.968
IGFBP1
Insulin-like growth factor-binding protein 1.
   
 0.966
IGF2R
Cation-independent mannose-6-phosphate receptor.
    
 
 0.956
EGFR
Receptor protein-tyrosine kinase.
    
 0.924
GPC3
Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
     
 0.916
FGFR4
Fibroblast growth factor receptor.
     
 0.906
FLT1
Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
     
 0.906
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.