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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPPL2BSignal peptide peptidase-like 2B isoform X1. (650 aa)    
Predicted Functional Partners:
TNF
Tumor necrosis factor; Belongs to the tumor necrosis factor family.
     
 0.790
STK11IP
Serine/threonine-protein kinase 11-interacting protein.
   
    0.782
SPATA5
Spermatogenesis-associated protein 5 isoform X1.
      
 0.608
FAM78B
Protein FAM78B.
      
 0.605
FAM78A
Protein FAM78A.
      
 0.605
ADAM10
Disintegrin and metalloproteinase domain-containing protein 10.
   
  
 0.550
FBXO6
F-box only protein 6.
      
 0.526
ENSVVUP00000000136
annotation not available
      
 0.505
TMEM106B
Transmembrane protein 106B.
      
 0.505
RUFY4
RUN and FYVE domain-containing protein 4.
      
 0.495
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.